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., 1997). It was confirmed this lionwin55 rtp impact was mediated in the CB1 receptor and occurred in a dose which was not linked to noticeable Unwanted effects. This study also demonstrated a rise in thermal hyperalgesia and mechanical allodynia by administration of SR141716a alone, foremost the authors to infer the existence of an endogenous tone of cannabinoid analgesia in neuropathy. On the other hand, the proof for this sort of tone all through inflammation is controversial (Beaulieu et al